There are several factors that cause skin aging, most commonly including exposure to ultraviolet radiation, oxidative stress, swelling, and deprivation of the extracellular matrix in accordance with hyperpigmentation of the skin, in which hormones contribute to the darkening of the skin. Phenolic, a bioactive agent, is involved in the treatment of skin aging as well as it has wide efficacy in the purpose of skin lightening.
In the original study, lychee serum was developed and its safety and efficacy were clinically evaluated voluntarily in humans. It was found that skin lightening effect, skin elasticity and as well as reduction in wrinkles was statistically significant. In short, efficacy and safety of lychee serum was confirmed for the treatment of hyperpigmentation and aging of skin.
There are some topical formulations such as glycolic acid, kojic acid, and hydroquinone which are considered first line option for the treatment of hyperpigmentation; furthermore, oral formulations such as cysteamine hydrochloride, melatonin, tranexamic acid are also included. In second line therapy chemical peel and laser therapy is considered but it must be strictly under the supervision of expert professionals. But these therapies have some limitations due to adverse effects such as erythema, drying of skin, peeling of skin, and it requires longer time to wait for the results.
Additionally, hyperpigmentation can be maintained and prevented from sunscreens for the protection from sun or ultraviolet radiations.
References:
- Lourith N, Kanlayavattanakul M. Formulation and clinical evaluation of the standardized Litchi chinensis extract for skin hyperpigmentation and aging treatments. Annales Pharmaceutiques Françaises. 2020;78(2):142-9.
- Nautiyal A, Wairkar S. Management of hyperpigmentation: Current treatments and emerging therapies. Pigment Cell & Melanoma Research. 2021;34(6):1000-14.
Also Read:
- Vitamin E – Miraculous Treatment Of Hyperpigmentation
- Post Inflammatory Hyperpigmentation: Dark Spots from Acne
About the Author: Dr. Iqra Mubashar is a registered Pharmacist originally from Lahore, Pakistan. She has earned her pharmacy degree from the University of veterinary and animal sciences, Lahore. She has completed her internship as a trainee from Children hospital, Lahore. She has completed her research work in clinical pharmacy and pharmaceutics. She has worked as a healthcare documentation head in Al-Qasim enterprises, Islamabad. She has specialized in prescription handling, drugs information, literature research, patient counseling, and pharmaceutical care planning. Her research work on coronavirus is under publication.
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